Genetics of obesity can be considered a hot item, so often some new discovery is worth your attention. There has been a research, made clear that if a specific mutation of a gene, can cause mice metabolism slowed down, stop burning fat, even if not the same will eat more fat.Another study showed that the high correlation between obesity and asthma, as many causes of asthma and obesity in part, to provide more clues for future treatments.
Fasting gene mistakes, mice become super fat
There vivo gene promoting diet , also have to stop eating gene, which if something goes wrong, it is out of control. Children's Hospital Boston study found that mice of Mrap2 genes (humans have) If the mutation, even if they eat as much as mice, mice have a genetic mutation that would fertilizer. Director of endocrinology Joseph Majzoub said gene mutation in mice that did not burn fat, as if someone ordered them to retain the same fat, while they were in obese people who have a similar variation phenomenon discovered.
This was published in "Science" journal study showed that the protein produced by the gene Mrap2 will stimulate brain receptors Mc4r, so ordered the brain to reduce appetite and increase metabolism, so if Mrap2 Mc4r gene mutation or change, it will interfere with brain functioning, so easy to accumulate fat bio.
They will all mouse genes Mrap2 body removal, or just remove the part of the brain, found that mice in both cases are generally twice the weight, weight grow up to the former, and if they are fed high-fat food, fat is even more exaggerated, male mice were much fat off than female mice. Focused, eat no more, but no Mrap2 gene in mice fat faster.
In the human body, after they find relevant evidence, in 500 severe, early-onset obesity in patients who find the same four variations appear. Although the single point of view on this study, the proportion of such variations causing obesity less than 1%, but the researchers believe that there should be other genetic variants have not found, but the interaction between genetic variation and environmental factors will enhance the generation of obesity.
High correlation between obesity and asthma
Causes of asthma are many reasons, in addition to our more familiar allergies, genetic and other reasons, obesity also accounted for one cause, but perhaps you would think people just because of fat, it will be insufficient lung capacity (gas) asthma. One published in the Journal of Obesity (Obesity) Online research shows that obesity, type II diabetes and asthma were highly relevant, not because of the relationship between human fat not run.
The study enrolled 22 normal weight and 23 obese participants, among which there are 11 otherwise type II diabetes, as well as more than 15 BMI 40 or 35 years but have had obesity-related diseases in patients with morbid obesity . All subjects without asthma, therefore the experimental results have particular significance.
Study found that four of asthma and chronic inflammatory genes associated with obesity or morbid obesity related, some related exceeds 100%, not surprisingly is the highest connected morbidly obese patients. These genes cause white blood cells caused by inflammation of the factors making too much, causing inflammation of the bronchi, triggering asthma.
Scientists also found two kinds of high-fat plasma concentrations of asthma-related compounds: MMP-9 and NOM. And did gastric bypass surgery in morbidly obese patients with diabetes, not only weight loss, MMP-9, NOM reduction, and reduce the impact of asthma-related genes, diabetes symptoms also improved.
Research writer who SUNY Buffalo, Dr. Paresh Dandona said that this is the first one from the perspective of biological and immunological relationship between obesity and asthma, unlike in the past but considered obese compressed lung capacity only. But more importantly, the recognition of obesity, diabetes and asthma height between connected.The next step will be a weight loss clinical studies to further relations with asthma.
Relevant information
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
Genetic mutation linked to severe obesity
Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: Reduction with weight loss
Obesity and asthma: Study finds a link in the genes
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
Genetic mutation linked to severe obesity
Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: Reduction with weight loss
Obesity and asthma: Study finds a link in the genes
